| ORIGINAL ARTICLES |
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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg. |
| Han Zhang1,2, Hong-Tao Zhu1, Dong Wang1, Chong-Ren Yang1, Ying-Jun Zhang1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 University of Chinese Academy of Sciences, Beijing 100049, China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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Abstract Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.
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| Keywords
Aspergillus penicilliodes Speg.
Indolyl diketopiperazines
Trypostatins
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| Fund:This work was supported by the National Natural Science Foundation of China (No. 21672223). The authors are grateful to the staffs of the analytical and bioactivity screening groups at State Key Laboratory of Phytochemistry and Plant Resources in West China, KIB, CAS, for measuring the spectroscopic data and bioactivities. |
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Corresponding Authors:
Ying-Jun Zhang
E-mail: zhangyj@mail.kib.ac.cn
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Issue Date: 26 April 2018
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