| Original article |
|
|
|
|
|
A Strategy to Employ Clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression |
| A.Anita Margret1, T.Nargis Begum2, S.Parthasarathy3, S.Suvaithenamudhan3 |
1. Department of Biotechnology and Bioinformatics, Bishop Heber College, Tiruchirappalli 620017, India;
2. Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli 620020, India;
3. Department of Bioinformatics, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, India |
|
|
|
|
Abstract Ayurveda is a renowned traditional medicine practiced in India from ancient times and Clitoria ternatea is one such prospective medicinal herb incorporated as an essential constituent in a brain tonic called as medhya rasayan for treating neurological disorders. This work emphasises the significance of the plant as a brain drug there by upholding Indian medicine. The phytochemicals from the root extract were extricated using gas chromatography-mass spectrometry assay and molecular docking against the protein Monoamine oxidase was performed with four potential compounds along with four reference compounds of the plant. This persuades the prospect of C. ternatea as a remedy for neurodegenerative diseases and depression. The in silico assay enumerates that a major compound(Z)-9, 17-octadecadienal obtained from the chromatogram with a elevated retention time of 32.99 furnished a minimum binding affinity energy value of-6.5 kcal/mol against monoamine oxidase(MAO-A). The interactions with the amino acid residues ALA 68, TYR 60 and TYR 69 were analogous to the reference compound kaempferol-3-monoglucoside with a least score of -13.90/-12.95 kcal/mol against the isoforms(MAO) A and B. This study fortifies the phytocompounds of C. ternatea as MAO-inhibitors and to acquire a pharmaceutical approach in rejuvenating Ayurvedic medicine.
|
| Keywords
(Z)-9, 17-Octadecadienal
Kaempferol-3-monoglucoside
Monoamine oxidase
Clitoria ternatea
Molecular docking
Ayurvedic medicine
|
|
Issue Date: 11 February 2018
|
|
|
1. P.K. Mukherjee, S. Rai, V. Kumar, K. Mukherjee, P.J. Hylands, R.C. Hider, Expert Opin. Drug Dis. 2, 633-657 (2007)
2. P.V. Sharma, Drauyaguna-Vijnana, vol. 2 (Chaukhambha Bharti Academy, Varanasi, 1998), pp. 3-29
3. K.C. Chuneker, Bhavaprakasa Nighantu, 6th edn. (Chaukhambha Bharti Academy, Varanasi, 1982), pp. 202-203
4. K.M. Nadkarni, Indian Materia Medica, vol. 1 (Popular Prakashan, Mumbai, 1976), pp. 9-10
5. A. Nahata, V.K. Dixit, Indian J. Pharm. Sci. 70, 834-837 (2008)
6. A. Nahata, U.K. Patil, V.K. Dixit, Nat. Prod. Res. 22, 1472-1482 (2008)
7. A. Nahata, U.K. Patil, V.K. Dixit, Pharm. Biol. 47, 444-451 (2009)
8. A. Nahata, U.K. Patil, V.K. Dixit, Phytother. Res. 24, 486-493 (2010)
9. N.K. Sethiya, A. Nahata, V.K. Dixit, Asian J. Tradit. Med. 3, 224-229 (2008)
10. V.V. Sivaranjan, I. Balachandran, Ayurvedic drugs and their plant sources (Oxford and IBH Publishing Company, New Delhi, 1994), pp. 425-428
11. A.W.J. Bach, N.C. Lan, D.L. Johnson, C.W. Abell, M.E. Bembenek, S.W. Kwan, P.H. Seeburg, J.C. Shih, Proc. Natl. Acad. Sci. 85, 4934-4938 (1998)
12. F. Hubalek, C. Binda, A. Khalil, M. Li, A. Mattevi, N. Castagnoli, D.E. Edmondson, J. Biol. Chem. 280, 15761-15766 (2005)
13. M.B.H. Youdim, D.E. Edmondson, K.F. Tipton, Nat. Rev. Neurosci. 7, 295-309 (2006)
14. J.W. Buckholtz, A. Meyer-Lindenberg, Trends Neurosci. 31(3), 120-129 (2008)
15. H. Dorfman, A. Meyer-Lindenberg, J.W. Buckholtz, Curr. Top Behav. Neurosci. 75(1), 9-17 (2014)
16. K.A. Pavlov, D.A. Chistiakov, V.P. Chekhonin, J. Appl. Genet. 53(1), 61-82 (2012)
17. C.M. Pare, Pharmakopsychiatr. Neuropsychopharmakol. 9, 187-192 (1976)
18. J. Shih, K. Chen, M.J. Ridd, Annu. Rev. Neurosci. 22, 197-217 (1999)
19. C. Binda, F. Hubalek, M. Li, D.E. Edmondson, A. Mattevi, FEBS Lett. 564, 225-228 (2004)
20. J.W. Tetrud, J.M. Langston, Science 245, 519-522 (1989)
21. Anonymous, Indian Medicinal Plants, 2nd edn. (Orient Longman, Madras, 1995), pp. 129-132
22. A.D. Taranalli, T.C. Cheeramkuczhi, Pharm. Biol. 38, 51-56 (2000)
23. K.S. Rai, K.D. Murthy, K.S. Karanth, M.S. Rao, Indian J. Physiol. Pharmacol. 45, 305-315 (2001)
24. J.R. Hibbeln, The Lancet 351(9110), 1213 (1998)
25. M. Peet, B. Murphy, J. Shay, D. Horrobin, Biol. Psychiatry 43, 315-319 (1998)
26. B. Peet, C. Stokes, Drugs 65, 1051-1059 (2005)
27. G. Uma, V. Balasubramaniam, J. Chem. Pharm. Res. 4, 4417-4419 (2012)
28. D.A. Finn, A.S. Beadles-Bohling, E.H. Beckley, M.M. Ford, K.R. Gililland, R.E. Gorin-Meyer, K.M. Wiren, CNS Drug Rev. 12, 53-76 (2006)
29. F.V. DeFeudis, K. Drieu, Drug Dev. Res. 62, 1-25 (2004)
30. P.C. Chan, Q.S. Xia, P.P. Fu, J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 25, 211-244 (2007)
31. C.J. Fehske, K. Leuner, W.E. Muller, Pharmacol. Res. 60, 68-73 (2009)
32. L. Ren, F. Wang, Z. Xu, W.M. Chan, C. Zhao, H. Xue, Biochem. Pharmacol. 79, 1337-1344 (2010)
33. K. Dhawan, S. Dhawan, A. Sharma Passiflora, J. Ethnopharmacol. 94, 1-23 (2004)
34. D.H. Kim, S.J. Jeon, K.H. Son, J.W. Jung, S. Lee, B.H. Yoon, J.J. Lee, Y.W. Cho, J.H. Cheong, Neurobiol. Learn. Mem. 87, 536-546 (2007)
35. V. Vingtdeux, U. Dreses-Werringloer, H. Zhao, P. Davies, P. Marambaud, BMC Neurosci. 9, S2-S6 (2008)
36. D. Commenges, V. Scotet, S. Renaud, H. Jacqmin-Gadda, P. Barberger-Gateau,J.F.Dartigues, Eur. J.Epidemiol. 16, 357-363(2000)
37. F.P. Turkmenoglu, İ. Baysal, S.C. Yabanoglu, K. Yelekci, H. Temel, S. Pas;a, N. Ezer, İ. C alis;, G. Ucar, Molecules 20, 7454-7473 (2015)
38. K. Kazuma, K. Kogawa, N. Noda, N. Kato, M. Suzuki, Chem Biodivers. 1, 1762-1770 (2004)
39. K. Kazuma, N. Noda, M. Suzuki, Phytochemistry 62, 229-237 (2003)
40. T. Kondo, M. Ueda, T. Goto, Tetrahedron Lett. 46, 4749-4756 (1990) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
