Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from <i>Hypericum cohaerens</i>

doi:10.1007/s13659-014-0007-5

Natural Products and Bioprospecting

2014, Vol. 4

Issue (2) : 73-79 DOI: 10.1007/s13659-014-0007-5

Original article

Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens

Jing-Jing Zhang^1,2, Xing-Wei Yang^1,2, Jun-Zeng Ma¹, Xia Liu¹, Li-Xin Yang¹, Sheng-Chao Yang³, Gang Xu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China

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Abstract Four new polycyclic polyprenylated acylphloroglucinol type metabolites, hypercohones D-G(1-4), along with four known analogues(5-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of these isolates were elucidated by extensive spectroscopic methods. The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.

Keywords Guttiferae Hypericum cohaerens Acylphloroglucinol Hypercohones D-G

Fund:The work was financially supported by the foundations from NSFC(20972167), the Young Academic Leader Raising Foundation of Yunnan Province(No. 2009CI073), and the foundation from CAS to Dr G. Xu.

Issue Date: 11 February 2018

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Jing-Jing Zhang,Xing-Wei Yang,Jun-Zeng Ma, et al. Hypercohones D-G, New Polycyclic Polyprenylated Acylphloroglucinol Type Natural Products from Hypericum cohaerens[J]. Natural Products and Bioprospecting, 2014, 4(2): 73-79.

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http://npb.kib.ac.cn/EN/10.1007/s13659-014-0007-5 OR http://npb.kib.ac.cn/EN/Y2014/V4/I2/73

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