Hypercohones A-C, acylphloroglucinol derivatives with <i>homo</i>-adamantane cores from <i>Hypericum cohaerens</i>

doi:10.1007/s13659-013-0032-9

Natural Products and Bioprospecting

2013, Vol. 3

Issue (5) : 233-237 DOI: 10.1007/s13659-013-0032-9

Regular Article

Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

Xia LIU^a,b, Xing-Wei YANG^a,b, Chao-Qun CHEN^a, Chun-Yan WU^a, Jing-Jing ZHANG^a,b, Jun-Zeng MA^a, Huan WANG^a, Qin-Shi ZHAO^a, Li-Xin YANG^a, Gang XU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract Three new homo-adamantanyl type natural products were derived from polyprenylated polycyclic acylphloroglucinol. Hypercohones A-C (1-3), along with five other known hypercohones (4-8), were isolated from the aerial parts of Hypericum cohaerens. The structures of 1-3 were elucidated on the basis of comprehensive spectroscopic analysis. The inhibitory activities of these isolates against five human cancer cell lines in vitro were tested.

Keywords Hypericum cohaerens adamantane acylphloroglucinol hypercohone

Fund:The work was financially supported by the foundations from NSFC (20972167), the Young Academic Leader Raising Foundation of Yunnan Province (No. 2009CI073), and the foundation from CAS to Dr Gang Xu.

Issue Date: 11 February 2018

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	Xia LIU
	Xing-Wei YANG
	Chao-Qun CHEN
	Chun-Yan WU
	Jing-Jing ZHANG
	Jun-Zeng MA
	Huan WANG
	Qin-Shi ZHAO
	Li-Xin YANG
	Gang XU

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Xia LIU,Xing-Wei YANG,Chao-Qun CHEN, et al. Hypercohones A-C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens[J]. Natural Products and Bioprospecting, 2013, 3(5): 233-237.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0032-9 OR http://npb.kib.ac.cn/EN/Y2013/V3/I5/233

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