Four new lanostane triterpenoids featuring extended <i>π</i>-conjugated systems from the stems of <i>Kadsura coccinea</i>

doi:10.1007/s13659-023-00376-1

Natural Products and Bioprospecting

2023, Vol. 13

Issue (2) : 12-12 DOI: 10.1007/s13659-023-00376-1

Original Article

Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Qi-Qi Zhang^1,2, Kun Hu¹, Han-Dong Sun¹, Pema-Tenzin Puno¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China

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Abstract Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM.

Keywords Kadsura coccinea Lanostane triterpenoids Extended π-conjugated systems Quantum chemical calculation

Fund:We thank Service Center for Bioactivity Screening, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany for bioactivity screening. This project was supported financially by the Natural Science Foundation of Yunnan Province (No. 202101AT070188).

Corresponding Authors: Pema-Tenzin Puno,E-mail:punopematenzin@mail.kib.ac.cn E-mail: punopematenzin@mail.kib.ac.cn

Issue Date: 18 May 2023

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Qi-Qi Zhang,Kun Hu,Han-Dong Sun, et al. Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea[J]. Natural Products and Bioprospecting, 2023, 13(2): 12-12.

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http://npb.kib.ac.cn/EN/10.1007/s13659-023-00376-1 OR http://npb.kib.ac.cn/EN/Y2023/V13/I2/12

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