Furan Derivatives and Polyketides from the Fungus <i>Irpex lacteus</i>

doi:10.1007/s13659-020-00282-w

Natural Products and Bioprospecting

2021, Vol. 11

Issue (2) : 215-222 DOI: 10.1007/s13659-020-00282-w

ORIGINAL ARTICLES

Furan Derivatives and Polyketides from the Fungus Irpex lacteus

Meng Wang¹, Zheng-Hui Li¹, Masahiko Isaka², Ji-Kai Liu¹, Tao Feng¹

1 School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China;
2 National Center for Genetic Engineering and Biotechnology(BIOTEC), 113 Thailand Science Park, Pathumthani 12120, Thailand

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Abstract Eight new furan derivatives, irpexins A-H (1-8), two new polyketides, irpexins I and J (9 and 10), together with nine known compounds were isolated from the fermentation of Irpex lacteus. The structures and absolute configurations were elucidated on the basis of extensive spectroscopic methods and Mosher ester reaction. All compounds shows no cytotoxicity to human MCF-7 and Hela cancer cell lines at the concentration of 10 μM.

Keywords Irpex lacteus Furan derivatives Polyketides

Fund:This work was financially supported by the joint research project from the National Natural Science Foundation of China (Grant No. 21961142008) and Thailand Research Fund (Grant No. DBG6280008). The authors thank Analytical & Measuring Centre, South-Central University for Nationalities for the spectra measurements.

Corresponding Authors: Tao Feng E-mail: tfeng@mail.scuec.edu.cn

Issue Date: 07 April 2021

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Meng Wang,Zheng-Hui Li,Masahiko Isaka, et al. Furan Derivatives and Polyketides from the Fungus Irpex lacteus[J]. Natural Products and Bioprospecting, 2021, 11(2): 215-222.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00282-w OR http://npb.kib.ac.cn/EN/Y2021/V11/I2/215

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