| ORIGINAL ARTICLES |
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Chemical Constituents from the Whole Plant of Cuscuta reflexa |
| Tin Thu Thu Aung1,3, Meng-Yuan Xia1, Pyae Phyo Hein1,3, Rong Tang1, Dong-Dong Zhang1,4, Jun Yang1,4, Xue-Fei Yang1,4, Dong-Bao Hu2, Yue-Hu Wang1,4 |
1 Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
4 Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar |
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Abstract Two new 2H-pyran-2-one glucosides, cuscutarosides A (1) and B (2), and one new steroidal glucoside, 7β-methoxy-β-sitosterol 3-O-β-glucopyranoside (3), together with 12 known compounds (4-15) were isolated from the whole plant of Cuscuta reflexa (Convolvulaceae) collected from Myanmar. The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis. The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase (PPL), and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin, plateletactivating factor (PAF), arachidonate (AA), or collagen. 7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside (3) showed weak PPL inhibitory activity. Cuscutaroside A (1), its acetylated derivative (1a), and scrophenoside B (8) showed weak inhibitory activity against rabbit platelet aggregation induced by collagen. Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.
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| Keywords
Cuscuta reflexa
Porcine pancreatic lipase
Platelet aggregation
2H-pyran-2-one glucosides
Steroidal glucosides
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| Fund:This study was supported by the Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences (Grant Nos. 2015CASEABRIRG001 and Y4ZK111B01), the International Partnership Program of Chinese Academy of Sciences (Grant No. 153631KYSB20160004), the National Natural Science Foundation of China (31960480), the Joint Special Project of Local Undergraduate Universities in Yunnan Province, China (Grant No. 2018FH001-024), and the Second Tibetan Plateau Scientific Expedition and Research (STEP) Program of Ministry of Science and Technology of the People’s Republic of China (Grant No. 2019QZKK0502). |
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Corresponding Authors:
Dong-Bao Hu, Yue-Hu Wang
E-mail: lh@yxnu.edu.cn;wangyuehu@mail.kib.ac.cn
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Issue Date: 23 October 2020
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