Cucurbitane-Type Triterpene Glycosides from <i>Momordica charantia</i> and Their <i>α</i>-Glucosidase Inhibitory Activities

doi:10.1007/s13659-020-00241-5

Natural Products and Bioprospecting

2020, Vol. 10

Issue (3) : 153-161 DOI: 10.1007/s13659-020-00241-5

ORIGINAL ARTICLES

Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities

Ya Gao^1,2, Jian-Chao Chen¹, Xing-Rong Peng¹, Zhong-Rong Li¹, Hai-Guo Su^1,2, Ming-Hua Qiu^1,2,3

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming 650201, People's Republic of China

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Abstract Ten cucurbitane-type triterpene glycosides, including five new compounds named charantosides H (1), J (2), K (3), momorcharacoside A (4), goyaglycoside-L (5), and five known compounds (6-10), were isolated from the EtOAc extract of Momordica charantia fruits. The chemical structures of these compounds were identified by 1D and 2D NMR and HRESIMS spectroscopic analyses. Configurations of new compounds were determined by ROESY correlations and comparison of their ¹³C NMR data with literature reported values. All compounds were evaluated for their inhibition against α-glucosidase, in which compounds 2, 5, 7, 8, 9 showed moderate inhibitory activities with IC₅₀ values ranging from 28.40 to 63.26 μM comparing with the positive control (acarbose, IC₅₀ 87.65±6.51 μM).

Keywords Momordica charantia Cucurbitane-type triterpene glycosides α-Glucosidase inhibitory activity

Fund:The work was supported by a program of the National Natural Science Foundation of China (Nos. 31872675 and 81373288) and the cooperation program between Chinese Academy of Sciences and Guangdong Province (2013B09110011).

Corresponding Authors: Ming-Hua Qiu E-mail: mhchiu@mail.kib.ac.cn

Issue Date: 02 June 2020

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Ya Gao,Jian-Chao Chen,Xing-Rong Peng, et al. Cucurbitane-Type Triterpene Glycosides from Momordica charantia and Their α-Glucosidase Inhibitory Activities[J]. Natural Products and Bioprospecting, 2020, 10(3): 153-161.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00241-5 OR http://npb.kib.ac.cn/EN/Y2020/V10/I3/153

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