| ORIGINAL ARTICLES |
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A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi |
| Xiu-Rong Wu1,2, Yi Shen1,2, Shu-Jun Cui1,2, Xiao-Lei Luo1,2, Chao-Jiang Xiao2, Bei Jiang1 |
1 Institute of Materia Medica, Dali University, Xueren Road 2, Dali 671000, People's Republic of China;
2 College of Pharmacy and Chemistry, Dali University, Xueren Road 2, Dali 671000, People's Republic of China |
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Abstract One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8±13.3% at the dose of 30 mg/kg/day.
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| Keywords
Dobinea delavayi
Anacardiaceae
Noreudesmane sesquiterpenoid
Antimalarial activity
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| Fund:This work was financially supported by the National Natural Science Foundation of China (Nos. 81960637 and 81460532), and the Innovation Team Project of Dali University for the Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines (No. ZKLX2019106). |
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Corresponding Authors:
Chao-Jiang Xiao, Bei Jiang
E-mail: xiaochaojiang@yeah.net;jiangbei@dali.edu.cn
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Issue Date: 06 May 2020
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