| ORIGINAL ARTICLE |
|
|
|
|
|
Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay |
| Chang-An Geng1,2, Meng-Hong Yan1,2, Xue-Mei Zhang1,2, Ji-Jun Chen1,2,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
3 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
|
|
|
|
Abstract A new flavane,bropapyriferol (1),and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay.The structure of compound 1 was determined by extensive 1D and 2D NMR,[α]D spectroscopic data and quantum computation.Daphnegiravan F (2) and 5,7,3',4'-tetrahydroxy-3-methoxy-8,5'-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro.Especially,compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis(MIC=1.95 ppm) than the positive control,triclosan.
|
| Keywords
Bropapyriferol
Broussonetia papyrifera
Anti-oral microbial activity
|
| Fund:This work was financially supported by the Program of Yunling Scholarship,the CAS "Light of West China" Program (Western Youth Scholars "A"),the Youth Innovation Promotion Association CAS (2013252),and the Applied Basic Research Programs of Yunnan Province (2017FB137). |
|
Corresponding Authors:
Ji-Jun Chen
E-mail: chenjj@mail.kib.ac.cn
|
|
Issue Date: 04 April 2019
|
|
|
1. J. González-Lorca, A. Rivera-Hutinel, X. Moncada, S. Lobos, D. Seelenfreund, A. Seelenfreund, N. Z. J. Bot. 53, 75-89(2015)
2. R.H. Ji, X.F. Lin, W.B. Zhang, S.L. Bai, China For. Prod. Ind. 44, 3-6(2017)
3. Y. Ding, J. Qiu, X.Y. Liu, Nat. Prod. Res. Dev. 26(1327-1331), 1337(2014)
4. H.W. Ryu, B.W. Lee, M.J. Curtis-Long, S. Jung, Y.B. Ryu, W.S. Lee, K.H. Park, J. Agric. Food Chem. 58, 202-208(2010)
5. H.H. Ko, W.L. Chang, T.M. Lu, J. Nat. Prod. 71, 1930-1933(2008)
6. S.C. Fang, B.J. Shieh, R.R. Wu, C.N. Lin, Phytochemistry 38, 535-537(1995)
7. D. Lee, K.P.L. Bhat, H.H.S. Fong, N.R. Farnsworth, J.M. Pezzuto, A.D. Kinghorn, J. Nat. Prod. 64, 1286-1293(2001)
8. H.W. Ryu, M.J. Curtis-Long, S. Jung, Y. Jeong, D.S. Kim, K.Y. Kang, K.H. Park, Food Chem. 132, 1244-1250(2012)
9. Z.M. Li, J.J. Chen, M.H. Yan, Med. Plant 1, 33-35(2010)
10. Q. Sun, F.F. Li, D. Wang, J. Wu, G.D. Yao, X. Li, L.Z. Li, Q.B. Liu, X.X. Huang, S.J. Song, RSC Adv. 6, 55919-55929(2016)
11. J. Kwon, N.T. Hiep, D.W. Kim, S. Hong, Y. Guo, B.Y. Hwang, H.J. Lee, W. Mar, D. Lee, J. Nat. Prod. 79, 1938-1951(2016)
12. L. Cui, H.S. Lee, D.T. Ndinteh, J.T. Mbafor, Y.H. Kim, T.V.T. Le, P.H. Nguyen, W.K. Oh, Planta Med. 76, 713-718(2010)
13. F.J. Guo, L. Feng, C. Huang, H.X. Ding, X.T. Zhang, Z.Y. Wang, Y.M. Li, Phytochemistry Lett. 6, 331-336(2013)
14. J. Matsumoto, T. Fujimoto, C. Takino, M. Saitoh, Y. Hano, T. Fukai, T. Nomura, Chem. Pharm. Bull. 33, 3250-3256(2008)
15. T. Mitsuo, A. Masaki, M. Tadashi, S. Akira, T. Kokichi, Chem. Lett. 3, 339-340(1980)
16. Z.Q. Yin, J.F. Chao, L.H. Zhang, W.C. Ye, W.B. Shen, S.X. Zhao, Nat. Prod. Res. Dev. 18(420-422), 425(2006)
17. S.S. Jia, C.M. Ma, J.M. Wang, Acta Pharm. Sin. 25, 758-762(1990)
18. S.C. Fang, B.J. Shieh, C.N. Lin, Phytochemistry 37, 851-853(1994)
19. S.S. Jia, D. Liu, X.P. Zheng, Y. Zhang, Y.K. Li, Acta Pharm. Sin. 28, 28-31(1993)
20. F. Machumi, G. Bojase-Moleta, R. Mapitse, I. Masesane, R.R.T. Majinda, Nat. Prod. Comm. 1, 287-292(2006)
21. L.S. Ding, Q.L. Liang, Y.F. Teng, Acta Pharm. Sin. 32, 600-602(1997)
22. J.F. Liu, Z.Y. Jiang, C.A. Geng, X.B. Zou, Y. Shi, Y.B. Ma, X.M. Zhang, J.J. Chen, Planta Med. 76, 1464-1467(2010) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
