| Original article |
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Spiralosides A-C, Three New C27-Steroidal Glycoalkaloids from the Fruits of Solanum spirale |
| Dan Li1,2, Yun-Li Zhao1, Xu-Jie Qin1, Lu Liu1,2, Xing-Wei Yang1, Ying-Ying Chen1,2, Bei Wang1,2, Xin Wei1,2, Ya-Ping Liu1, Xiao-Dong Luo1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China |
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Abstract Three new C27-steroidal glycoalkaloids, spiralosides A-C (1-3), were obtained from the total alkaloids of Solanum spirale by chromatographic methods. On the basis of spectroscopic evidence, spiralosides A-C were elucidated as (22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl (1), (22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl (2), (22R,25S)-22,26-epiminocholest-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl (3), respectively. The total alkaloids of S. spirale have been screened for their antitussive and expectorant effects in intact animal model.
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| Keywords
Solanaceae
Solanum spirale
Spiralosides A-C
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| Fund:The authors are grateful to the Natural Science Foundation of China (81225024);and to the analytical group of the Laboratory of Phytochemistry,Kunming Institute of Botany for spectral measurements |
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Issue Date: 08 February 2018
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