Ypsiyunnosides A-E, Five New Cholestanol Glycosides from <i>Ypsilandra yunnanensis</i>

doi:10.1007/s13659-016-0098-2

Natural Products and Bioprospecting

2016, Vol. 6

Issue (3) : 173-182 DOI: 10.1007/s13659-016-0098-2

Original article

Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis

Yu Chen^1,2, Yong-Ai Si^1,2, Wei Ni¹, Huan Yan¹, Xu-Jie Qin¹, Chang-Xiang Chen¹, Hai-Yang Liu¹

1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2. University of Chinese Academy of Sciences, Beijing 100039, China

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Abstract Phytochemicalinvestigationonthewholeplantsof Ypsilandrayunnanensiswascarriedoutforthefirsttimeandledtothe isolation of five new cholestanol glycosides, ypsiyunnosides A-E (1-5), and one known analogue. Their structures were determined mainly by detailed spectroscopic analysis, including extensive 1D and 2D NMR, MS and UV, as well as chemical methods. Among them, compound 1 possessed a rare 6/6/6/5/5 fused-rings cholestanol sketelon, which was identified as (23R,25R)-3β,16α,26-triol- 16,23-cyclocholest-5,17(20)-dien-22-one. Their induced platelet aggregation activities and cytotoxicities were evaluated.

Keywords Ypsilandra yunnanensis Liliaceae Cholestane glycoside Ypsiyunnosides A-E

Fund:This work was supported by the National Natural Science Funding of China (Grants 31170333 and 31570363)

Issue Date: 08 February 2018

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Yu Chen,Yong-Ai Si,Wei Ni, et al. Ypsiyunnosides A-E, Five New Cholestanol Glycosides from Ypsilandra yunnanensis[J]. Natural Products and Bioprospecting, 2016, 6(3): 173-182.

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http://npb.kib.ac.cn/EN/10.1007/s13659-016-0098-2 OR http://npb.kib.ac.cn/EN/Y2016/V6/I3/173

1. The Editorial Board of Flora of China, Flora of China (Science Press, Beijing, 1980), p. 17
2. B.B. Xie, H.Y. Liu, W. Ni, C.X. Chen, Y. Lu, L. Wu, Q.T. Zheng, Chem. Biodivers. 3, 1211-1218 (2006)
3. B.B. Xie, H.Y. Liu, W. Ni, C.X. Chen, Steroids 74, 950-955 (2009)
4. Y. Lu, C.X. Chen, W. Ni, H.Y. Liu, Steroids 75, 982-987 (2010)
5. Y. Lu, B.B. Xie, C.X. Chen, W. Ni, H. Yan, H.Y. Liu, Helv. Chim. Acta 94, 92-97 (2011)
6. H.Y. Liu, C.X. Chen, Y. Lu, J.Y. Yang, W. Ni, Nat. Prod. Bioprospect. 2, 11-15 (2012)
7. X.D. Zhang, C.X. Chen, J.Y. Yang, W. Ni, H.Y. Liu, Helv. Chim. Acta 95, 1087-1093 (2012)
8. B.B. Xie, C.X. Chen, Y.H. Guo, Y.Y. Li, Y.J. Liu, W. Ni, L.M. Yang, N.B. Gong, Y.T. Zheng, R.R. Wang, Y. Lu, H.Y. Liu, Planta Med. 79, 1063-1067 (2013)
9. Y.A. Si, H. Yan, W. Ni, Z.H. Liu, T.X. Lu, C.X. Chen, H.Y. Liu, Nat. Prod. Bioprospect. 4, 315-318 (2014)
10. C.M. Xiao, J. Huang, X.M. Zhong, X.Y. Tang, Helv. Chim. Acta 92, 2587-2595 (2009)
11. P.K. Agrawal, Steroids 70, 715-724 (2005)
12. P.K. Agrawal, Phytochemistry 31, 3307-3330 (1992)
13. R. Kasai, M. Okihara, J. Asakawa, K. Mizutani, O. Tanaka, Tetrahedron 35, 1427-1432 (1979)
14. Yunnan Food, Drug Administration, The Yunnan Chinese Materia Medica Standards ((Yi Nationality Medicine (Ⅲ)) (Yunnan Scientific and Technological Press, Kunming, 2010), pp. 5-6
15. G.V.R. Born, Nature 194, 927-929 (1962)
16. G.V.R. Born, J. Physiol. 168, 178-195 (1963)
17. T. Mosmann, J. Immunol. Methods 65, 55-63 (1983)

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