| Original article |
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Cycloartane Glycosides from the Roots of Cimicifuga foetida with Wnt Signaling Pathway Inhibitory Activity |
| Di-Fan Zhu, Guo-Lei Zhu, Ling-Mei Kong, Ni-Man Bao, Lin Zhou, Yin Nian, Ming-Hua Qiu |
| State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China |
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Abstract Four new 9, 19-cycloartane triterpenoids, cimilactone E(1), cimilactone F(2), 20-O-(E)-butenoyl-23-epi-26-deoxyactein(3), and 20, 12β-O-diacetylcimiracemonol-3-O-β-D-xylopyranoside(4), together with four known constituents(5-8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC50 values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.
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| Keywords
Cimicifuga foetida
9, 19-Cycloartane triterpenoids
Cimilactone-type
Wnt signal pathway
Luciferase activity
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| Fund:This project was supported by Program for National Natural Science Foundation of China(Nos. U1132604 and 81302670), The Major Deployment Program of the CAS(No. KSZDEW-Z-004-01), and Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2008-ZZ05). |
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Issue Date: 11 February 2018
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1. K.M. Cadigan, R. Nusse, Genes Dev. 11, 3286-3305 (1997)
2. X.Y. Li, Y.Y. Wang, C.G. Yuan, X.J. Hao, Y. Li, Nat. Prod. Bioprospect. 3, 24-28 (2013)
3. A. Gregorieff, H. Clevers, Genes Dev. 2005(19), 877-890 (2005)
4. Pharmacopoeia Commission of the People's Republic of China, The Pharmacopoeia of Chinese People's Republic (The Chemical Industry Publishing House, Beijing, 2010), pp. 68-69
5. Y. Nian, M.X. Zhang, Y. Li, Y.Y. Wang, J.C. Chen, L. Lu, L. Zhou, M.H. Qiu, Phytochemistry 72, 1473-1481 (2011)
6. Y. Nian, H.Y. Wang, J. Su, L. Zhou, M.H. Qiu, Fitoterapia 83, 293-297 (2012)
7. L. Lu, J.C. Chen, Y. Li, C. Qing, Y.Y. Wang, Y. Nian, M.H. Qiu, Chem. Pharm. Bull. 60, 571-577 (2012)
8. D.S. Li, Y. Nian, Y. Sun, M.H. Qiu, Helv. Chim. Acta 94, 632-638 (2011)
9. L.R. Sun, J. Yan, L. Lu, S.J. Pei, Z.R. Li, L. Zhou, X.M. Zhang, M.H. Qiu, Helv. Chim. Acta 90, 1313-1318 (2007)
10. L. Lu, J.C. Chen, H.J. Song, Y. Li, Y. Nian, M.H. Qiu, Chem. Pharm. Bull. 58, 729-733 (2010)
11. D.F. Zhu, Y. Nian, H.Y. Wang, Z.R. Zhang, Y.B. Song, R.T. Li, M.H. Qiu, J. Nat. Med. 12, 0294-0296 (2014)
12. H.Y. Wang, Y. Nian, C.Y. Ma, J.Q. Liu, Y.B. Song, L. Zhou, M.H. Qiu, Chin. J. Chem. 30, 1265-1268 (2012)
13. Y. Nian, H.Y. Wang, L. Zhou, J. Su, Y. Li, M.H. Qiu, Planta Med. 79, 60-69 (2013)
14. Y. Nian, H. Zhu, W.R. Tang, Y. Luo, J. Du, M.H. Qiu, J. Nat. Prod. 76, 896-902 (2013)
15. Y. Liu, D. Chen, J. Si, G. Tu, D. An, J. Nat. Prod. 65, 1486-1488 (2002)
16. Y. Nian, H.Y. Wang, L. Zhou, J. Su, Y. Li, M.H. Qiu, Planta Med. 78, 1-10 (2012)
17. L.R. Sun, C. Qing, Y.L. Zhang, S.Y. Jia, Z.R. Li, S.J. Pei, M.H. Qiu, L.G. Michael, X.Q. Samuel, Beilstein J. Organ. 3(3) (2007)
18. Y.S. Fan, W. Jia, A.H. Zhao, J. Tang, H.Q. Duan, Chin. Chem. Lett. 17, 1477-1480 (2006)
19. S.N. Chen, W. Li, D.S. Fabricant, B.D. Santarsiero, A. Mesecar, J.F. Fitzloff, H.H.S. Fong, N.R. Farnsworth, J. Nat. Prod. 65, 601-605 (2002)
20. Z. Tian, R.L. Pan, J.Y. Si, P.G. Xiao, Fitoterapia 77, 39-42 (2006)
21. J.Y. Chen, P.L. Li, X.L. Tang, X.L. Tang, S.J. Wang, Y.T. Jiang, L. Shen, B.M. Xu, Y.L. Shao, G.Q. Li, J. Nat. Prod. 77, 1997-2005 (2014)
22. Y. Shao, A. Harris, M. Wang, H. Zhang, A.C. Geoffrey, M. Bowman, E. Lemmo, J. Nat. Prod. 63, 905-910 (2000) |
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