| Original article |
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Protective Role of C-Phycocyanin Against Secondary Changes During Sodium Selenite Mediated Cataractogenesis |
| Rasiah Pratheepa Kumari, Kumarasamy Anbarasu |
| Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India |
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Abstract Age related cataract is the leading cause of blindness associated with accumulation of oxidative stress in the eye lens. The present investigation reveals the rational of the beneficial effects of the natural compound C-phycocyanin(CPC) is beneficial when administered to rat pups to protect against the secondary effects of sodium selenite induced cataractogenesis. A single subcutaneous dose of sodium selenite(19 μmol/kg body weight) on the 10th day of postpartum is adequate to induce cataract in rat pups. Serum biochemical parameters, such as the level of electrolytes, mean activities of anti-oxidant enzymes i. e. superoxide dismutase, catalase and reduced glutathione were observed to be significantly altered during selenite induced cataractogenic process. Histopathological examination revealed signs of degradation of normal cell architecture in the liver, kidney and eye lens. Interestingly, the deleterious effects of sodium selenite toxicity were restored with the simultaneous treatment with C-PC. The results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium selenite. These results complement the beneficial role of C-PC of cyanobacterial origin as a efficacious anti-cataractogenic agent against sodium selenite toxicity.
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| Keywords
Cyanobacteria
C-phycocyanin
Cataract
Sodium selenite
Cataractogenesis
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| Fund:The authors gratefully acknowledge DSTPURSE, DST-Fast Track(YS) for financial assistance in the form of fellowship and project grant to the first and the corresponding authors respectively. The authors record their thanks to Dr. K. Selvakumar, Mrs. S. Bavithra and Mr. S. Balaji for helping with the histological analysis. |
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Issue Date: 11 February 2018
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