<i>neo</i>-Clerodane diterpenoids from <i>Salvia dugesii</i> and their bioactive studies

doi:10.1007/s13659-011-0016-6

Natural Products and Bioprospecting

2011, Vol. 1

Issue (2) : 81-86 DOI: 10.1007/s13659-011-0016-6

Regular Article

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

Gang XU^a, Fang ZHAO^b, Xian-Wen YANG^c, Juan ZHOU^b, Li-Xin YANG^a, Xiao-Ling SHEN^b, Ying-Jie HU^b, Qin-Shi ZHAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Tropical Medicine Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China;
c Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

Abstract
References
Related Articles
Metrics

Download: PDF(781 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C-G(1-5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was noteworthy that the eleven isolates, composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton, were reported from the same plant for the first time. The anti-feedantial, cytotoxic, and antiviral activities of the isolates were evaluated. Dugesin F(4) was tested to be a non-toxic antiviral compound against influenza virus FM1.

Keywords Salvia dugesii neo-clerodane diterpenoids dugesins antivirus

Fund:This work was supported financially by the National Basic Research Program of China(2009CB522300), the National Natural Science Foundation of China(No. 20702054), Shanghai Landscaping Administration Bureau Program(G102404), the foundation from the Chinese Academy of Sciences(2010KIBA10), and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No. 2009CI073).

Issue Date: 24 November 2017

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Gang XU
	Fang ZHAO
	Xian-Wen YANG
	Juan ZHOU
	Li-Xin YANG
	Xiao-Ling SHEN
	Ying-Jie HU
	Qin-Shi ZHAO

Trendmd:

Cite this article:

Gang XU,Fang ZHAO,Xian-Wen YANG, et al. neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies[J]. Natural Products and Bioprospecting, 2011, 1(2): 81-86.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-011-0016-6 OR http://npb.kib.ac.cn/EN/Y2011/V1/I2/81

[1]	Song, H.; Kong, W. F. Fifteen invasive plants in Kunming. http://www.shxb.net/html/20060715/20060715_34599.shtml.
[2]	Merritt, A. T.; Ley, S. V. Nat. Prod. Rep. 1992, 9, 243-287.
[3]	Rodriguez-Hahn, L.; O'Reilly, R.; Esquivel, B.; Maldonado, E.; Ortega, A.; Cardenas, J.; Toscano, R. A. J. Org. Chem. 1990, 55, 3522-3525.
[4]	Rodriguez-Hahn, L.; Esquivel, B.; Sanchez, A. A.; Cardenas, J.; Tovar, O. G.; Soriano-Garcia, M.; Toscano, A. J. Org. Chem. 1988, 53, 3933-3936.
[5]	Esquivel, B.; Dominguez, R. M.; Hernandez-Ortega, S.; Toscano, R. A.; Rodriguez-Hahn, L. Tetrahedron 1994, 50, 11593-11600.
[6]	Esquivel, B.; Tello, R.; Sanchez, A. A. J. Nat. Prod. 2005, 68,787-790.
[7]	Munro, T. A.; Rizzacasa, M. A.; Rpth, B. L.; Toth, B. A.; Yan, F. J. Med. Chem. 2005, 48, 345-348.
[8]	Xu, G.; Peng, L. Y.; Niu, X. M.; Zhao, Q. S.; Li, R. T.; Sun, H. D. Helv. Chim. Acta 2004, 87, 949-955.
[9]	Xu, G.; Yang, J.; Wang, Y. Y.; Peng, L. Y.; Yang, X. W.; Pan, Z. H.; Liu, E. D.; Li, Y.; Zhao, Q. S. J. Agric. Food Chem. 2010, 58, 12157-12161.
[10]	Xu, G.; Hou, A. J.; Zheng, Y. T.; Zhao, Y.; Li, X. L.; Peng, L. Y.; Zhao, Q. S. Org. Lett. 2007, 9, 291-293.
[11]	Savona, G.; Raffa, D.; Bruno, M.; Rodriguez, B. Phytochemistry 1983, 22, 784-786.
[12]	Rodriguez, B.; Pascual, C.; Savona, G. Phytochemistry 1984, 23, 1193-1194.
[13]	Esquivel, B.; Cardenas, J.; Toscano, A.; Soriano-Garcia, M.; Rodriguez-Hann, L. Tetrahedron 1985, 41, 3213-3217.
[14]	Bisio, A.; Fontana, N.; Romussi, G.; Ciarallo, G.; Tommasi, N. S. D.; Pazza, C.; Mugnoli, A. Phytochemistry 1999, 52, 1535-1540.
[15]	Aoyagi, Y.; Yamazaki, A.; Nakatsugawa, C.; Fukaya, H.; Takeya, K.; Kawauchi, S.; Izumi, H.; Salvileucalin B. Org. Lett. 2008, 10, 4429-4432.
[16]	Guo, P.; Li, Y. S.; Xu, J.; Liu, C. Z.; Ma, Y. G.; Guo, Y. Q. J. Nat. Prod. 2011, 74, 1575-1583.
[17]	Givovich, A.; San-Martin, A.; Castillo, M. Phytochemistry 1986, 25, 2829-2831.
[18]	Gebbinck, E. A. K.; Jansen, B. J. M.; Groot, A. Phytochemistry 2002, 61, 737-770.
[19]	Fu, L. C.; Xu, P. P.; Liu, N.; Yang, Z. F.; Zhang, F. X.; Hu, Y. J. Trad. Chin. Drug Res. & Clin. Pharm. 2008, 19, 266-269.
[20]	Li, H. Y.; Yang, L.; Liu, W.; Zuo, J. Acta Physio. Sinica 2011, 25, 69-74.
[21]	Mosmann, T. J. Immunol. Methods 1983, 65, 55-63.
[22]	Carpinelia, M. C.; Defago, M. T.; Balladares, G.; Palacios, S. M. J. Agric. Food Chem. 2003, 51, 369-374.

No related articles found!

Viewed

Full text

Abstract

Cited

Shared

Discussed