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Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound |
| Abdallah Rhihil2, Youness Aichi1, Mohamed Zahouily3, Sa?d Sebti1, Mohamed El Guendouzi1 |
1 Laboratory of Chemistry Physics Materials and Catalysis (LCPMC), Faculty of Sciences Ben M'sik of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
2 Financial Engineering, Governance and Development Laboratory, National School of Business and Management of Casablanca, Hassan II University of Casablanca, Casablanca, Morocco;
3 Laboratory of Materials, Catalysis and Valorization of Natural Resources, Faculty of Sciences and Technology of Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco |
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Abstract Spiropyrimidines vanquish a significant situation in the field of heterocyclic chemistry, they are broadly utilized as an antibacterial, an inhibitor of multidrug opposition, or an antiplatelet and antithrombotic drug. Phosphate, the principal Moroccan mineral wealth occupies a vital spot in the economic sector and its valuation is a goal continually looked for. Among the conceivable outcomes of valorization, its utilization in heterogeneous catalysis which thought about an exceptionally encouraging new way. In this context, the focus on the reaction of the synthesis of spiropyrimidine, catalyzed by natural phosphate (NP) and by fluoroapatite (Fap), are used alone or doped by cobalt. These phosphate catalysts were characterized by XRD, IR and SEM, while the synthesized spiropyrimidine was identified by IR, GC–MS and NMR. The obtained yield with fluorapatite doped by cobalt (Co/Fap), at room temperature in ethanol is very high and shows a high impact performance induced by a synergistic effect compared to that of NP alone.
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| Keywords
Spiropyrimidine
Natural phosphate
Co/Fap
Heterogeneous catalysis
Multicomponent reaction
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Corresponding Authors:
Abdallah Rhihil,E-mail:a.rhihil@encgcasa.ma
E-mail: a.rhihil@encgcasa.ma
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Issue Date: 12 October 2022
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