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New seco-anthraquinone glucoside from the roots of Rumex crispus |
| Yong-Xiang Li1,2, Na Li1, Jing-Juan Li1, Man Zhang1, Hong-Tao Zhu1, Dong Wang1, Ying-Jun Zhang1,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China |
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Abstract A new seco-anthraquinone, crispuside A (1), and three new 3,4-dihydronaphthalen-1(2H)-ones, napthalenones A-C (2–4), were isolated from the roots of Rumex crispus L., along with 10 known anthraquinones (6–14) and naphthalenone (5). Their structures were fully determined by extensive spectroscopic analyses, including ECD, and X-ray crystallography in case of compound 5, whose absolute configuration was determined for the first time. The isolates 1, 6–14 were evaluated for their anti-inflammatory and anti-fungal activity against three skin fungi, e.g., Epidermophyton floccosum, Trichophyton rubrum, and Microsporum gypseum. Most of the isolates showed weak antifungal and anti-inflammatory activity. Only compound 9 exhibited obvious anti-fungal activity against E. floccosum (MIC50 = 2.467 ± 0.03 μM) and M. gypseum ( MIC50 = 4.673 ± 0.077 μM), while the MIC50 values of the positive control terbinafine were 1.287 ± 0.012 and 0.077 ± 0.00258 μM, respectively. The results indicated that simple emodin type anthraquinone is more potential against skin fungi than its oxyglucosyl, C-glucosyl and glycosylated seco analogues.
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| Keywords
Polygonaceae
Rumex crispus L.
Anthranoids
Anti-fungal activity
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| Fund:This research was supported by Ministry of Science and Technology of the People's Republic of China,2021YFE0103600. |
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Corresponding Authors:
Ying Jun Zhang,E-mail:zhangyj@mail.kib.ac.cn
E-mail: zhangyj@mail.kib.ac.cn
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Issue Date: 12 October 2022
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