| ORIGINAL ARTICLES |
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Ypsilandrosides U-Y, five new steroidal saponins from Ypsilandra thibetica |
| Wen-Tao Gao1,2, Ling-Ling Yu2,3, Jing Xie2,3, Long-Gao Xiao2,3, Shi-Juan Zhang2,3, Wen-Yi Ma2,3, Huan Yan2, Hai-Yang Liu2 |
1 College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China;
3 University of Chinese Academy of Sciences, Beijing, 100049, China |
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Abstract Phytochemical reinvestigation on the whole plants of Ypsilandra thibetica obtained four new spirostanol glycosides, named ypsilandrosides U-X (1–4), and one new cholestanol glycoside, named ypsilandroside Y (5). Their structures have been established by extensive spectroscopic data and chemical methods. Among them, compound 4 is a rare spirostanol glycoside which possesses a novel 5(6 → 7) abeo-steroidal aglycone, while compound 1 is a first spirostanol bisdesmoside attached to C-3 and C-12, respectively, isolated from the genus Ypsilandra. The induced platelet aggregation activity of the isolates was tested.
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| Keywords
Ypsilandra thibetica
Melanthiaceae
Ypsilandrosides U-Y
Spirostanol saponins
Cholestanol saponins
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| Fund:This work was financially supported by the National Natural Science Foundation of China (U1802287 and 32000280), the Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents, and the State Key Laboratory of Phytochemistry and Plant Resources in West China (P2019-ZZ02). |
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Corresponding Authors:
Hai-Yang Liu,E-mail:haiyangliu@mail.kib.ac.cn
E-mail: haiyangliu@mail.kib.ac.cn
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Issue Date: 24 June 2022
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