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α-C(sp3)-H Arylation of Cyclic Carbonyl Compounds |
| Mei Wang1, Wei Wang1, Dashan Li1, Wen-Jing Wang1, Rui Zhan2, Li-Dong Shao1 |
1 Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650050, China;
2 School of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650050, China |
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Abstract α-C(sp3)-H arylation is an important type of C-H functionalization. Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via C-H functionalization. Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams. The α-C(sp3)-H arylation of these compounds have been exhibited high efficiency in forming C(sp3)-C(sp2) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities. This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of α-C(sp3)-H arylations of cyclic carbonyl compounds in recent years.
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| Keywords
C-H functionalization
α-C(sp3)-H arylation
Cyclic carbonyl compounds
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| Fund:We gratefully acknowledge financial support from the National Science of Foundation of China (81960631), the Yunnan Fundamental Research Project (202001AS070038), the Top Young Talent of Ten Thousand Talents Program of Yunnan Province (R. Zhan and L.-D Shao), and the Start-up Fund of Yunnan University of Chinese Medicine (2019YZG03). |
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Corresponding Authors:
Rui Zhan, Li-Dong Shao
E-mail: sunnyzhanrui@126.com;shaolidong@ynutcm.edu.cn
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Issue Date: 30 July 2021
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