| ORIGINAL ARTICLES |
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Isoprenylated Flavonoids as Cav3.1 Low Voltage-Gated Ca2+ Channel Inhibitors from Salvia digitaloides |
| Jian-Jun Zhao1,2, Song-Yu Li1,2, Fan Xia1, Ya-Li Hu1,2, Yin Nian1, Gang Xu1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract Saldigones A-C (1, 3, 4), three new isoprenylated flavonoids with diverse flavanone, pterocarpan, and isoflavanone architectures, were characterized from the roots of Salvia digitaloides, together with a known isoprenylated flavanone (2). Notably, it's the first report of isoprenylated flavonoids from Salvia species. The structures of these isolates were elucidated by extensive spectroscopic analysis. All of the compounds were evaluated for their activities on Cav3.1 low voltage-gated Ca2+ channel (LVGCC), of which 2 strongly and dose-dependently inhibited Cav3.1 peak current.
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| Keywords
Salvia digitaloides
Isoprenylated flavonoid
Cav3.1 low voltage-gated Ca2+ channel (LVGCC)
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| Fund:The work was financially supported by the Foundation of Supported by National Natural Science Foundation of China (32070392 and 32070393) and the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502-0303). |
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Corresponding Authors:
Yin Nian, Gang Xu
E-mail: nianyin@mail.kib.ac.cn;xugang008@mail.kib.ac.cn
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Issue Date: 10 December 2021
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