Adipogenesis Inhibitory Activity of Hypersampsone P from <i>Hypericum subsessile</i>

doi:10.1007/s13659-020-00245-1

Natural Products and Bioprospecting

2020, Vol. 10

Issue (3) : 163-170 DOI: 10.1007/s13659-020-00245-1

ORIGINAL ARTICLES

Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile

Hui-Min Zhou^1,2, Yan-Song Ye^1,2, Na-Na Jiang^1,2, Rong-Fang Mu^1,2, Qian Wang^1,2, Jing Hu¹, Xia Liu³, Wan-Ying Qin^1,2, Gang Xu^1,2, Wen-Yong Xiong^1,2

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3 Department of Pharmacy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China

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Abstract Adamantane polycyclic polyprenylated acylphloroglucinols (PPAPs) with caged architecture, a special class of hybrid natural products, is specifically rich in the plant family Guttiferae, especially Hypericum or Garcinia genus. Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile. Here we have chosen, screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation. Particularly, the compound, hypersampsone P, blunted the adipocyte differentiation dose-dependently. Moreover, hypersampsone P down-regulated the expressions of several key regulators for adipogenesis, including PPARγ and FABP4. The treatment of cells at the early stage of adipogenesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.

Keywords Adipogenesis LKB1 AMPK Hypericum subsessile Hypersampsone P

Fund:The work was supported by Yunnan Provincial Science and Technology Department, China (2017FA044), and Chongqing Municipal Natural Science Foundation (cstc2018jcyjAX0388).

Corresponding Authors: Gang Xu, Wen-Yong Xiong E-mail: xugang008@mail.kib.ac.cn;xiong.wenyong@mail.kib.ac.cn

Issue Date: 02 June 2020

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	Hui-Min Zhou
	Yan-Song Ye
	Na-Na Jiang
	Rong-Fang Mu
	Qian Wang
	Jing Hu
	Xia Liu
	Wan-Ying Qin
	Gang Xu
	Wen-Yong Xiong

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Hui-Min Zhou,Yan-Song Ye,Na-Na Jiang, et al. Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile[J]. Natural Products and Bioprospecting, 2020, 10(3): 163-170.

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http://npb.kib.ac.cn/EN/10.1007/s13659-020-00245-1 OR http://npb.kib.ac.cn/EN/Y2020/V10/I3/163

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