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Chemical Constituents from Mentha haplocalyx Briq. (Mentha canadensis L.) and Their α-Glucosidase Inhibitory Activities |
| Xiao-Feng He1,2,3, Chang-An Geng1,2, Xiao-Yan Huang1,2, Yun-Bao Ma1,2, Xue-Mei Zhang1,2, Ji-Jun Chen1,2,3 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China;
3 University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Mentha haplocalyx (Mentha canadensis) is widely used as a medicinal plant in traditional Chinese medicine, and the extracts of its aerial parts are found to significantly inhibit the activity of α-glucosidase with an IC50 value of 21.0 μg/mL. Bioactivity-guided isolation of the extracts afforded two new compounds (1 and 2), together with 23 known ones (3-25). Their structures were established by extensive spectroscopic analyses (1D and 2D NMR, MS, IR and UV). Compounds 1-17 and 21-25 were evaluated for their α-glucosidase inhibitory activities. Compound 11 was the most active ones with an IC50 values of 83.4 μM. These results verify the α-glucosidase inhibitory activity of M. haplocalyx (M. canadensis) and specify its active compounds for the first time.
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| Keywords
Mentha haplocalyx Briq. (Mentha canadensis L.)
Lamiaceae
α-Glucosidase inhibitor
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| Fund:This work was supported by the CAS Hundred Talents Program, the Youth Innovation Promotion Association of the Chinese Academy of Sciences (CN), and Southeast Asia Biodiversity Research Institute, CAS (2017CASSEABRIQG003). |
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Corresponding Authors:
Ji-Jun Chen
E-mail: chenjj@mail.kib.ac.cn
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Issue Date: 05 June 2019
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