| ORIGINAL ARTICLES |
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Diverse Polyphenols from Hypericum faberi |
| Xin-Wen Zhang1,2, Yan-Song Ye1,2, Fan Xia1, Xing-Wei Yang1, Gang Xu1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
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Abstract Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A-F (1-6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12-13 were isoprenylated xanthones, hyperfaberols C-E (3-5) and 8-11 were seven isoprenylated acylphloroglucinol derivatives, while 6-7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively.
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| Keywords
Hypericum faberi
Isoprenylated xanthone
Isoprenylated acylphloroglucinol
Chromone
Cytotoxicitiy
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| Fund:The work was financially supported by the foundations from Kunming Institute of Botany (KIB2017001), Southeast Asia Biodiversity Research Institute (2017CASSEABRIQG003), CAS, and Yunnan Key Laboratory of Natural Medicinal Chemistry (S2017-ZZ11 and 2015-ZZ07). |
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Corresponding Authors:
Xin-Wen Zhang
E-mail: xugang008@mail.kib.ac.cn
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Issue Date: 05 June 2019
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