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Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi |
| Yan-Song Ye1,4, Man Wu2, Na-Na Jiang1,4, Yuan-Zhi Lao2, Wen-Wei Fu2, Xia Liu3, Xing-Wei Yang1, Juan Zhang2, Hong-Xi Xu2, Gang Xu1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
3 Department of Pharmacy, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China;
4 University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A-E (1-5), as well as seven known analogues (6-12), were characterized from Hypericum henryi. Their structures were determined by combination of NMR, ECD spectroscopy, and X-ray diffraction analysis. Compounds 1 and 6-8 were tested to exhibit potential antitumor properties, of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest. In addition, these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines, as well as suppress lung cancer A549 cells metastasis in vitro.
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| Keywords
Hypericum henryi
Dearomatized isoprenylated acylphloroglucinols (DIAPs)
Apoptosis
Cell cycle arrest
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| Fund:The work was financially supported by the NSFC-Joint Foundation of Yunnan Province (U1902213), Chongqing Municipal Natural Science Foundation (cstc2018jcyjAX0388), the Second Tibetan Plateau Scientific Expedition and Research (STEP) program (2019QZKK0502), Southeast Asia Biodiversity Research Institute, CAS (2017CASSEABRIQG003), State Key Laboratory of Phytochemistry and Plant Resources in West China (P2017-KF02 and P2019-ZZ05), and the Natural Sciences Foundation of Yunnan Province (2019FA003). |
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Corresponding Authors:
Hong-Xi Xu, Gang Xu
E-mail: xuhongxi88@gmail.com;xugang008@mail.kib.ac.cn
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Issue Date: 29 February 2020
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