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Brevipedicelones D and E, Two C-O-C Flavonoid Dimmers from the Leaves of Garcinia brevipedicellata and Anti-onchocercal Activity |
| Mirabel Akongwi1,2, Anastasie E. Tih1, Kennedy D. Nyongbela2, Moses Samje3, Raphael T. Ghogomu1, Bernard Bodo4 |
1 Department of Organic Chemistry, Faculty of Science, University of Yaounde 1, P. O. Box 812, Yaounde, Cameroon;
2 Pharmacochemistry Research Laboratory, Department of Chemistry, Faculty of Science, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
3 Faculty of Science, ANDI Centre of Excellence on Onchocerciasis Research, University of Buea, P. O. Box 63, Buea, South West Region, Cameroon;
4 Laboratoire de Chimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75005 Paris, France |
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Abstract A novel isoflavone-chromone flavonoid C-O-C dimmer, brevipedicelone D (1), along with one new C-O-C biflavonoid derivative, brevipedicelone E (2), were isolated from the ethyl acetate extract of the leaves of Garcinia brevipedicellata, a medicinal plant used in folk medicine in parts of Cameroon. Their structures were elucidated by extensive spectroscopic techniques, including 1D- and 2D- NMR, MS experiments, as well as comparing their spectral data with those of known analogues. Anti-onchocercal screening of 1 showed moderate inhibition of adult worm motility of Onchocerca ochengi by 60% at the highest concentration (20 μg/mL) and inhibited motility of both the juvenile worms of O. ochengi and Loa loa by 90% at this same concentration.
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Garcinia brevipedicellata
Brevipedicelone
Anti-onchocercal activity
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Corresponding Authors:
Mirabel Akongwi
E-mail: akongwimyra@gmail.com
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Issue Date: 28 January 2019
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