| REVIEWS |
|
|
|
|
|
Small-Molecule Targets in Tumor Immunotherapy |
| Hui-Fang Zhu1,2, Yan Li1 |
1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132#Lanhei Road, Kunming 650201, Yunnan, People's Republic of China;
2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China |
|
|
|
|
Abstract Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost. Therefore, alternative approaches including small-molecule-regulated immune response are being introduced. In this review, we focused on some of the key intracellular pathways where smallmolecule therapeutic is potential and attractive, which highlights the great potential of natural products in this field.
|
| Keywords
Cancer immunotherapy
IDO1
PD(L)-1
NKG2DL
STING
TLRs
|
| Fund:This work was supported financially by the funding of Exploitation and Utilization of Abundant Natural Products from Plants from Kunming Institute of Botany (KIB2017009), the National Natural Science Foundation of China (U1402227), the 100 Talents Program of the Chinese Academy of Sciences (Y. Li), the Program of Recruited Top Talent of Sciences and Technology of Yunnan Province (2009CI120) and the Independent Program of Key Laboratory of Natural Pharmaceutical Chemistry of Yunnan Province (Y. Li). |
|
Corresponding Authors:
Yan Li,liyanb@mail.kib.ac.cn
E-mail: liyanb@mail.kib.ac.cn
|
|
Issue Date: 28 August 2018
|
|
|
1. P. Letendre, V. Monga, M. Milhem, Y. Zakharia, Future Oncol. 13, 625-636 (2017)
2. J.D. Wolchok, F.S. Hodi, J.S. Weber, J.P. Allison, W.J. Urba, C. Robert, S.J. O'Day, A. Hoos, R. Humphrey, D.M. Berman, N. Lonberg, A.J. Korman, Ann. N. Y. Acad. Sci. 1291, 1-13 (2013)
3. S.J. Antonia, A. Villegas, D. Daniel, D. Vicente, S. Murakami, R. Hui, T. Yokoi, A. Chiappori, K.H. Lee, M. de Wit, B.C. Cho, M. Bourhaba, X. Quantin, T. Tokito, T. Mekhail, D. Planchard, Y.C. Kim, C.S. Karapetis, S. Hiret, G. Ostoros, K. Kubota, J.E. Gray, L. Paz-Ares, J. de Castro Carpeno, C. Wadsworth, G. Melillo, H. Jiang, Y. Huang, P.A. Dennis, M. Ozguroglu, P. Investigators, N. Engl. J. Med. 377, 1919-1929 (2017)
4. M.D. Copur, D. Gauchan, R. Ramaekers, N. Engl. J. Med. 378, 868 (2018)
5. D. Meininger, L. Zalameda, Y. Liu, L.P. Stepan, L. Borges, J.D. McCarter, C.L. Sutherland, Biochim. Biophys. Acta 1814, 1947-1954 (2011)
6. E. Vacchelli, F. Aranda, A. Eggermont, C. Sautes-Fridman, E. Tartour, E.P. Kennedy, M. Platten, L. Zitvogel, G. Kroemer, L. Galluzzi, Oncoimmunology 3, e957994 (2014)
7. C. Sheridan, Nat. Biotechnol. 33, 321-322 (2015)
8. D.A. Wainwright, M. Dey, A. Chang, M.S. Lesniak, Front. Immunol. 4, 116 (2013)
9. G.C. Prendergast, R. Metz, A.J. Muller, Cell Cycle 8, 1818-1819 (2009)
10. S.L. Topalian, C.G. Drake, D.M. Pardoll, Cancer Cell 27, 450-461 (2015)
11. A.D. Bardoli, M. Afshar, R. Viney, M. Foster, E. Porfiri, A. Zarkar, R. Stevenson, N.D. James, R.T. Bryan, P. Patel, Future Oncol. 12, 595-600 (2016)
12. P. Khanna, N. Blais, P.O. Gaudreau, L. Corrales-Rodriguez, Clin. Lung Cancer 18, 13-22 (2017)
13. R.J. Sullivan, K.T. Flaherty, Nat. Rev. Clin. Oncol. 12, 625-626 (2015)
14. R.J. Motzer, N.M. Tannir, D.F. McDermott, O. Aren Frontera, B. Melichar, T.K. Choueiri, E.R. Plimack, P. Barthelemy, C. Porta, S. George, T. Powles, F. Donskov, V. Neiman, C.K. Kollmannsberger, P. Salman, H. Gurney, R. Hawkins, A. Ravaud, M.O. Grimm, S. Bracarda, C.H. Barrios, Y. Tomita, D. Castellano, B.I. Rini, A.C. Chen, S. Mekan, M.B. McHenry, M. WindRotolo, J. Doan, P. Sharma, H.J. Hammers, B. Escudier, I. CheckMate, N. Engl. J. Med. 378, 1277-1290 (2018)
15. D.S. Bae, Y.K. Hwang, J.K. Lee, Cell. Immunol. 276, 122-127 (2012)
16. N. Nausch, A. Cerwenka, Oncogene 27, 5944-5958 (2008)
17. P. Nowbakht, M.C. Ionescu, A. Rohner, C.P. Kalberer, E. Rossy, L. Mori, D. Cosman, G. De Libero, A. Wodnar-Filipowicz, Blood 105, 3615-3622 (2005)
18. J. Shen, J. Pan, C. Du, W. Si, M. Yao, L. Xu, H. Zheng, M. Xu, D. Chen, S. Wang, P. Fu, W. Fan, Cell Death Dis. 8, e2740 (2017)
19. X. Wu, Y. Tao, J. Hou, X. Meng, J. Shi, Neoplasia 14, 1178-1189 (2012)
20. S. Shin, M. Kim, S.J. Lee, K.S. Park, C.H. Lee, Cancer Genomics Proteomics 14, 349-362 (2017)
21. S. Kiany, G. Huang, E.S. Kleinerman, Oncoimmunology 6, e1333214 (2017)
22. J.E. Butler, M.B. Moore, S.R. Presnell, H.W. Chan, N.J. Chalupny, C.T. Lutz, J. Immunol. 182, 6600-6609 (2009)
23. L. Shi, H. Lin, G. Li, Y. Sun, J. Shen, J. Xu, C. Lin, S. Yeh, X. Cai, C. Chang, Cancer Lett. 373, 45-56 (2016)
24. X. Lu, Z. Zhu, L. Jiang, X. Sun, Z. Jia, S. Qian, J. Li, L. Ma, Am. J. Transl. Res. 7, 1838-1849 (2015)
25. L. Ma, Z. Zhu, X. Lu, L. Jiang, M. Zhou, S. Qian, J. Li, Zhonghua Xue Ye Xue Za Zhi 35, 438-442 (2014)
26. S.R. Woo, L. Corrales, T.F. Gajewski, Trends Immunol. 36, 250-256 (2015)
27. L. Corrales, S.M. McWhirter, T.W. Dubensky Jr., T.F. Gajewski, J. Clin. Invest. 126, 2404-2411 (2016)
28. P. Nakhaei, J. Hiscott, R. Lin, J. Mol. Cell. Biol. 2, 110-112 (2010)
29. H. Ishikawa, G.N. Barber, Cell. Mol. Life Sci. 68, 1157-1165 (2011)
30. L. Corrales, S.R. Woo, J.B. Williams, S.M. McWhirter, T.W. Dubensky Jr., T.F. Gajewski, J. Immunol. 196, 3191-3198 (2016)
31. J. Wang, P. Li, M.X. Wu, J. Invest. Dermatol. 136, 2183-2191 (2016)
32. A. Sanchez Alberti, A.E. Bivona, N. Cerny, K. Schulze, S. Weissmann, T. Ebensen, C. Morales, A.M. Padilla, S.I. Cazorla, R.L. Tarleton, C.A. Guzman, E.L. Malchiodi, NPJ Vaccines 2, 9 (2017)
33. J.M. Weiss, M.V. Guerin, F. Regnier, G. Renault, I. Galy-Fauroux, L. Vimeux, V. Feuillet, E. Peranzoni, M. Thoreau, A. Trautmann, N. Bercovici, Oncoimmunology 6, e1346765 (2017)
34. E.J. Hennessy, A.E. Parker, L.A. O'Neill, Nat. Rev. Drug. Discov. 9, 293-307 (2010)
35. A.J. Smith, Y. Li, H.G. Bazin, J.R. St-Jean, D. Larocque, J.T. Evans, J.R. Baldridge, Vaccine 34, 4304-4312 (2016)
36. A.I. Rubin, E.H. Chen, D. Ratner, N. Engl. J. Med. 353, 2262-2269 (2005)
37. C. Guiducci, A.P. Vicari, S. Sangaletti, G. Trinchieri, M.P. Colombo, Cancer Res. 65, 3437-3446 (2005) |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
