New spinosin derivatives from the seeds of <i>Ziziphus mauritiana</i>

doi:10.1007/s13659-013-0028-5

Natural Products and Bioprospecting

2013, Vol. 3

Issue (3) : 93-98 DOI: 10.1007/s13659-013-0028-5

Regular Article

New spinosin derivatives from the seeds of Ziziphus mauritiana

Bin WANG^a,b, Hong-Tao ZHU^a, Dong WANG^a, Chong-Ren YANG^a, Min XU^a, Ying-Jun ZHANG^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China

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Abstract Three new acylated flavonoid C-glycosides, 6'''-(-)-phaseoylspinosin (1), 6'''-(3"",4"",5""-trimethoxyl)-(E)-cinnamoylspinosin (2), and 6'''-(4""-O-β-D-gluco-pyranosyl)-benzoylspinosin (3), were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae). A further 19 known compounds including eight spinosin analogues (4-11) were also isolated. Their structures were elucidated by means of spectroscopic analysis and chemical method. Among spinosin derivatives 1, 2, 4, 7, 8, and triterpenoid saponin 14, jujuboside A (14) displayed moderate acetylcholinesterase (AchE) inhibitory activity with an inhibition value of 46.2% at a concentration of 1 μM.

Keywords Ziziphus mauritiana Rhamnaceae seeds spinosin derivatives jujuboside A acetylcholinesterase inhibitory

Fund:We are grateful to the members of the analytical group of our institute for the measurement of spectroscopic data. The authors are sincerely grateful to Prof. Huai-Rong Luo for the AChE inhibitory activity bioassay. This work was supported by the 973 Program of Science and Technology of China (2011CB915503) and the Fourteenth Candidates of the Young Academic Leaders of Yunnan Province (Min Xu, 2011CI044).

Issue Date: 11 February 2018

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Bin WANG,Hong-Tao ZHU,Dong WANG, et al. New spinosin derivatives from the seeds of Ziziphus mauritiana[J]. Natural Products and Bioprospecting, 2013, 3(3): 93-98.

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http://npb.kib.ac.cn/EN/10.1007/s13659-013-0028-5 OR http://npb.kib.ac.cn/EN/Y2013/V3/I3/93

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