Cucurbitane triterpenoids from <i>Hemsleya penxianensis</i>

doi:10.1007/s13659-011-0044-2

Natural Products and Bioprospecting

2012, Vol. 2

Issue (4) : 138-144 DOI: 10.1007/s13659-011-0044-2

Regular Article

Cucurbitane triterpenoids from Hemsleya penxianensis

Jian-Chao CHEN^a, Lin ZHOU^a, Yun-Hua WANG^b, Ren-Rong TIAN^b, Yun-Xin YAN^a, Yin NIAN^a, Yun SUN^a, Yong-Tang ZHENG^b, Ming-Hua QIU^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

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Abstract Two new cucurbitacins, jinfushanencins A(1) and B(2), seven new cucurbitane glycosides, jinfushanosides E-K(3-9), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell(EC₅₀=5.9 μg/mL) with a selectivity index of 13.5.

Keywords cucurbitane triterpenoid jinfushanencin jinfushanoside Hemsleya penxianensis

Fund:This work was financially supported by the Natural Science Foundation of Yunnan Province(2008CD158), the Western Doctoral Foundation of Chinese Academy of Sciences(J. C. Chen), the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences(P2008ZZ23, P2010ZZ14), and the Cooperative Project of Guangdong Province and CAS(2009B091300135).

Issue Date: 11 February 2018

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	Jian-Chao CHEN
	Lin ZHOU
	Yun-Hua WANG
	Ren-Rong TIAN
	Yun-Xin YAN
	Yin NIAN
	Yun SUN
	Yong-Tang ZHENG
	Ming-Hua QIU

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Jian-Chao CHEN,Lin ZHOU,Yun-Hua WANG, et al. Cucurbitane triterpenoids from Hemsleya penxianensis[J]. Natural Products and Bioprospecting, 2012, 2(4): 138-144.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0044-2 OR http://npb.kib.ac.cn/EN/Y2012/V2/I4/138

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