Novel indole and quinoline alkaloids from <i>Melodinus yunnanensis</i>

doi:10.1007/s13659-011-0001-0

Natural Products and Bioprospecting

2011, Vol. 1

Issue (1) : 25-28 DOI: 10.1007/s13659-011-0001-0

Regular Article

Novel indole and quinoline alkaloids from Melodinus yunnanensis

Xiang-Hai CAI, Yan LI, Jia SU, Ya-Ping LIU, Xiao-Ning LI, Xiao-Dong LUO

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

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Abstract 6/7-Seco rearranged spiro-indolone alkaloids, meloyunines A(1) and B(2) and a monoterpenoid quinoline alkaloid meloyunine C(3) together with its possible intermediate 14, 15-dehydromelohenine B(4), and their precursor Δ¹⁴-vincamenine(5) were isolated from Melodinus yunnanensis. All structures were elucidated based on NMR, FTIR, UV, and MS spectroscopic data. The isolation of monoterpenoid indole, quinoline, and its immediate from the same plant chemically supported the biosynthesis of quinoline from indole. Compound 2 was cytotoxic against several human cancer cell lines

Keywords spiro-indolone quinoline meloyunine Melodinus yunnanensis

Fund:This work was supported in part by the National Natural Science Foundation of China(2107298), the 973 Program of Ministry of Science and Technology of P. R. China(2009CB522300), and Chinese Academy of Sciences(KSCX2-EW-R-15 and XiBuZhiGuang Project).

Issue Date: 10 November 2017

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	Xiao-Dong LUO

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Xiang-Hai CAI,Yan LI,Jia SU, et al. Novel indole and quinoline alkaloids from Melodinus yunnanensis[J]. Natural Products and Bioprospecting, 2011, 1(1): 25-28.

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http://npb.kib.ac.cn/EN/10.1007/s13659-011-0001-0 OR http://npb.kib.ac.cn/EN/Y2011/V1/I1/25

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