Three new nortriterpenoids from <i>Schisandra wilsoniana</i> and their anti-HIV-1 activities

doi:10.1007/s13659-011-0008-6

Natural Products and Bioprospecting

2011, Vol. 1

Issue (1) : 33-36 DOI: 10.1007/s13659-011-0008-6

Regular Article

Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities

Guang-Yu YANG^a,b, Yin-Ke LI^c, Xing-Jie ZHANG^d, Xiao-Nian LI^a, Liu-Meng YANG^d, Yi-Ming SHI^a, WeiLie XIAO^a, Yong-Tang ZHENG^d, Han-Dong SUN^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, Yunnan, China;
c School of Chemistry and Biotechnology, Yunnan Nationalities University, Kunming 650031, Yunnan, China;
d Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China

Abstract
References
Related Articles
Metrics

Download: PDF(713 KB) HTML ()
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks

Abstract Three new highly oxygenated nortriterpenoids, wilsonianadilactones D-F(1-3), were isolated from the leaves and stems of Schisandra wilsoniana. Their structures were established by means of spectroscopic analysis. Compounds 1-3 showed weak anti-HIV-1 activity with the therapeutic index(TI) values(CC₅₀/EC₅₀) greater than 8.16, 14.7, and 17.5, respectively.

Keywords nortriterpenoid wilsonianadilactone Schisandra wilsoniana

Fund:This project was supported financially by the NSFC(No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences(KSCX2-EW-Q-10, KSCX1-YW-R-24 and KSCX2-YW-R-185), the Major State Basic Research Development Program of China(No. 2009CB522303 and 2009CB940900), the Yong Academic and Technical Leader Rising Foundation of Yunnan Province(2006PY01-47), and the Natural Science Foundation of Yunnan Province(2005XY04 and 2006B0042Q).

Issue Date: 10 November 2017

	Service

	E-mail this article
	E-mail Alert
	RSS
	Articles by authors

	Guang-Yu YANG
	Yin-Ke LI
	Xing-Jie ZHANG
	Xiao-Nian LI
	Liu-Meng YANG
	Yi-Ming SHI
	WeiLie XIAO
	Yong-Tang ZHENG
	Han-Dong SUN

Trendmd:

Cite this article:

Guang-Yu YANG,Yin-Ke LI,Xing-Jie ZHANG, et al. Three new nortriterpenoids from Schisandra wilsoniana and their anti-HIV-1 activities[J]. Natural Products and Bioprospecting, 2011, 1(1): 33-36.

URL:

http://npb.kib.ac.cn/EN/10.1007/s13659-011-0008-6 OR http://npb.kib.ac.cn/EN/Y2011/V1/I1/33

[1]	Flora Yunnanica; Science Press:Beijing, 2000; Vol. 11, p 16.
[2]	Yang, G. Y.; Xiao, W. L.; Chang, Y.; Wang, R. R.; Pu, J. X.; Gao, X. M.; Lei, C.; Sun, H. D. Helv. Chim. Acta. 2008, 91, 1871-1878.
[3]	Ma, W. H.; Huang, H.; Zhou, P.; Chen, D. F. J. Nat. Prod. 2009, 72, 676-678.
[4]	Yang, Y. E.; Li, X. Q.; Tang, C. P. Chin. J. Nat. Med. 2011, 9, 7-16.
[5]	Zhang, X. J.; Yang, G. Y.; Wang, R. R.; Pu, J. X.; Sun, H. D.; Xiao, W. L.; Zheng, Y. T. Chem. Biodiv. 2010, 7, 2692-2701.
[6]	Yang, G. Y.; Li, Y. K.; Wang, R. R.; Xiao, W. L.; Yang, L. M.; Pu, J. X.; Zheng, Y. T.; Sun, H. D. J. Asian. Nat. Prod. Res. 2010, 12, 470-476.
[7]	Yang, G. Y.; Li. Y. K.; Wang. R. R.; Li, X. N.; Xiao, W. L.; Yang, L. M.; Pu, J. X.; Zheng, Y. T.; Sun, H. D. J. Nat. Prod. 2010, 73, 915-919.
[8]	Ma, W. H.; Lu, Y.; Huang, H.; Zhou, P.; Chen, D. F. Bioorg. Med. Chem. Lett. 2009, 19, 4958-4962.
[9]	Yang, G. Y.; Fan, P.; Wang, R. R.; Cao, J. L., Xiao, W. L.; Yang, L. M.; Pu, J. X.; Zheng, Y. T.; Sun, H. D. Chem. Pharm. Bull. 2010, 58, 734-737.
[10]	Li, R. T.; Zhao, Q. S.; Li, S. H.; Han, Q. B.; Sun, H. D.; Lu, Y.; Zhang, L. L.; Zheng, Q. T. Org. Lett. 2003, 5, 1023-1026.
[11]	Li, R. T.; Li, S. H.; Zhao, Q. S.; Lin, Z. W.; Sun, H. D.; Lu, Y.; Wang, C.; Zheng, Q. T. Tetrahedron Lett. 2003, 44, 3531-3534.
[12]	Xiao, W. L.; Li, R. T.; Li, S. H.; Li, X. L.; Sun, H. D.; Zheng, Y. T.; Wang, R. R.; Lu,Y.; Wang, C.; Zheng, Q. T. Org. Lett. 2005, 7, 1263-1266.
[13]	Xiao, W. L.; Zhu, H. J.; Shen, Y. H.; Li, R. T.; Li, S. H.; Sun, H. D.; Zheng, Y. T.; Wang, R. R.; Lu, Y.; Wang, C.; Zheng, Q. T. Org. Lett. 2005, 7, 2145-2148.
[14]	Xiao, W. L.; Li, R. T.; Huang, S. X.; Pu, J. X.; Sun, H. D. Nat. Prod. Rep. 2008, 25, 871-891.
[15]	Luo, X.; Chang, Y.; Zhang, X. J.; Pu, J. X.; Gao, X. M.; Wu, Y. L.; Wang, R. R.; Sun, H. D. Tetrahedron. Lett. 2009, 50, 5962-5964.
[16]	Lei, C.; Xiao, W. L.; Huang, S. X.; Chen, J. J.; Pu, J. X.; Sun, H. D. Tetrahedron 2010, 66, 2306-2310.
[17]	Lei, C.; Huang, S. X.; Xiao, W. L.; Li, X. N.; Pu, J. X.; Sun, H. D. J. Nat. Prod. 2010, 73, 1337-1343.
[18]	He, F.; Pu, J. X.; Huang, S. X.; Wang, Y. Y.; Xiao, W. L.; Li, L. M.; Liu, J. P.; Sun, H. D. Org. Lett. 2010, 12, 1208-1211.
[19]	Wang, R. R.; Yang, L. M.; Wang, Y. H.; Pang, W.; Tam, S. C.; Tien, P.; Zheng, Y. T. Biochem. Biophys. Res. Commun. 2009, 382, 540-544.

[1]	Da-Song YANG, Wei-Bing PENG, Zi-Lei LI, Xue WANG, Jian-Guo WEI, Ke-Chun LIU, Yong-Ping YANG, Xiao-Li LI. *Chemical constituents from the aerial parts of Euphorbia sikkimensis* and their bioactivities**[J]. Natural Products and Bioprospecting, 2013, 3(3): 112-116.

Viewed

Full text

Abstract

Cited

Shared

Discussed