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New polychlorinated bibenzyls from Rhododendron minutiflorum |
| Yang1, Li Zhu1, Li Deng1, Yu Tang1, Xian2, Zhe Fan3, Yang Han1, Mei Pan1 |
1 State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China;
2 Guangxi Key Laboratory of Citrus Biology, Guangxi Academy of Specialty Crops, Guilin 541004, People's Republic of China;
3 Guilin Pharma Company, Guilin 541007, People's Republic of China |
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Abstract Five new polychlorinated bibenzyls (1-5) along with 3 known compounds (6-8) were isolated from the stems and leaves of Rhododendron minutiflorum. The chemical structures of all the isolates were determined by spectroscopic methods, and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses. Compounds 1-5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures. Biologically, compounds 2, 5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid (Diaphorina citri) with LD50 values 27.15, 17.02 and 16.20 mg/L, respectively. These values were comparable to the positive control matrine (LD50 = 11.86 mg/L), which were calculated using observations on day 6. Meanwhile, compound 4 had α-glucosidase inhibitory activity with IC50 value of 17.87 ± 0.74 μM.
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| Keywords
Rhododendron minutiflorum
Polychlorinated bibenzyls
Matrine
Insecticidal activity
Diaphorina citri
α-Glucosidase inhibitory activity
Acarbose
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| Fund:This work was financially supported by The Natural Science Foundation of China (32160109, 31800294), the Natural Science Foundation of Guangxi Province of China (2018GXNSFBA138006, 2019AC20231), Educational Depart? ment of Guangxi (2018KY0089), the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (CMEMR2017?A07, 2020?A09), Joint cultivation base of biology and medicine graduate student between Guangxi Normal University and Guilin Pharma Company. |
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Corresponding Authors:
Li-Jun Zhang,E-mail:ajun840618@mailbox.gxnu.edu.cn;Hai-Bing Liao,E-mail:lhbing188@163.com
E-mail: ajun840618@mailbox.gxnu.edu.cn;lhbing188@163.com
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Issue Date: 08 March 2023
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