| ORIGINAL ARTICLES |
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Star fruit extract and C-glycosylated favonoid components have potential to prevent air pollutant-induced skin infammation and premature aging |
| Ping Wu1, Hiroyasu Iwahashi2, Hai-Hui Xie1, Ying Wang1, Yan-Yang Zhou2, Akinori Kiso2, Yoshihito Kawashima2, Xiao-Yi Wei1 |
| 1 Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Digital Botanical Garden and Public Science, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People’s Republic of China 2 Research Center, Maruzen Pharmaceuticals Co. Ltd., 1089-8 Sagata, Shin-ichi-Cho, Fukuyama-City, Hiroshima 729-3102, Japan |
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Abstract Air pollution adversely affects skin, leading to skin inflammation and premature skin aging. Plant derived antioxidant compounds have been considered to be promising in discovery of effective agents for the protection of skin from the damage by air pollutants. Our previous studies demonstrated that Averrhoa carambola fruit (known as star fruit) is rich in flavonoid C-glycosides with unique structures and potent antioxidant activity. Thus, the star fruit extract (SFE) and main flavonoid C-glycoside components, carambolasides I, J, and P (1–3), carambolaflavone B (4), and isovitexin 2″-O-α-L-rhamnoside (5), were investigated for the activity against air pollutant stress in human epidermis. As a result, SFE and compounds 1–5 exhibited significant inhibitory activity against protein carbonylation in oxidative-stressed stratum corneum with the best activity being shown by compound 3. SFE and compounds 2–5 were also active against engine exhaust-induced protein carbonylation in stratum corneum. When further evaluated, SFE and compound 3 significantly inhibited gene expression of the key inflammation mediators IL-1α and COX-2 in PM-stressed keratinocytes. The results indicated that SFE and the flavonoid C-glycosides are potentially effective against air pollutant-induced skin inflammation and premature aging.
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| Keywords
Star fruit
Carambolaside P
Air pollution
Protein carbonylation
Skin infammation
Premature skin aging
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| Fund:This work was partially supported by an NSFC grant (No. 31470423) and a spe- cial fund for natural resources afairs (2019KJCX027) from Forest Administra- tion of Guangdong Province, China. |
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Corresponding Authors:
Hiroyasu Iwahashi, E-mail:h-iwahashi@maruzenpcy.co.jp;Xiao-Yi Wei, E-mail:wxy@scbg.ac.cn
E-mail: h-iwahashi@maruzenpcy.co.jp;wxy@scbg.ac.cn
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Issue Date: 26 April 2022
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