| ORIGINAL ARTICLES |
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Clerodane-type Diterpene Glycosides from Dicranopteris pedata |
| Bei-Bei Gao2, Yu-Fei Ou1,2, Qin-Feng Zhu3, Zhi-Ping Zhou1,2, Zhen-Tao Deng1,2, Meng Li1,2, Qin-Shi Zhao2 |
1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Yunnan, 650091 Kunming, People's Republic of China;
2 State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
3 College of Pharmacy, Guizhou Medical University, Guian New Area, Guizhou 550025, China |
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Abstract Three new clerodane-type diterpene glycosides, (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl] cleroda-3,13(16),14-diene (1), (5R,6S,8R,9S,10R,13S)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-2-oxoneocleroda-3,13-dien-15-ol (2), (5R,6S,8R,9S,10R)-6-O-[β-D-glucopyranosyl-(1→ 4)-α-L-rhamnopyranosyl]-(13E)-2-oxoneocleroda-3,14-dien-13-ol (3), together with two known compounds 4 and 5 were isolated from Dicranopteris pedata. The structures of these compounds were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 2 was determined by ECD calculations. In addition, compound 1 exhibited weak inhibitory activities against SMMC-7721, MCF-7 and SW480.
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| Keywords
Dicranopteris pedata
Clerodane-type diterpene glycosides
ECD
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| Fund:This work is supported by the Natural Science Foundation of Yunnan province. (No. 202001AT070052) |
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Corresponding Authors:
Qin-Shi Zhao
E-mail: qinshizhao@mail.kib.ac.cn
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Issue Date: 27 September 2021
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