| ORIGINAL ARTICLES |
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Four New Limonoids from the Barks of Toona ciliata |
| Pan-Pan Zhang, Yun-Ge Bu, Shang Xue, Zhi-Rong Cui, Peng-Fei Tang, Jun Luo, Ling-Yi Kong |
| State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China |
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Abstract Four new limonoids, toonayunnanaes F-I (1-4), and six known compounds (5-10) were isolated from the barks of Toona ciliata. Their structures were elucidated by thoroughly analyzing of NMR and HRMS data, and single-crystal X-ray diffraction of 1. The oxetane ring moiety in 1 was rare in limonoids and other natural products. Compound 1 showed nitric oxide (NO) inhibitory effect with an IC50 38.45±0.41 μM in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.
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| Keywords
Meliaceae
Toona ciliate
Limonoids
NO inhibitory effects
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| Fund:Financial supports for this study were from the National Natural Science Foundation of China (31470416), the National New Drug Innovation Major Project (2018ZX09711-001-007), the National Key R&D Program of China (2018YFC1707105), and the "Double First-Class" University project (CPU2018GY08, China). |
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Corresponding Authors:
Jun Luo, Ling-Yi Kong
E-mail: luojun@cpu.edu.cn;cpu_lykong@126.com
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Issue Date: 11 March 2021
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