| ORIGINAL ARTICLE |
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Aristolane-type Sesquiterpenoids from Nardostachys chinensis and Revised Structure of Aristolanhydride |
| Li-Xia Wang1,2, Xian-Jun Jiang1,2, Xiang-Mei Li1,2, Mei-Fen Mao1,2, Guo-Zhu Wei1,2, Fei Wang1,2 |
1 BioBioPha Co., Ltd., Kunming 650201, People's Republic of China;
2 Reference Substances Sub-center, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming 650201, People's Republic of China |
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Abstract Four hitherto unknown aristolane-type sesquiterpenes,including one novel 8,9-secoaristolane,namely secoaristolenedioic acid (1),two aristolone derivatives,namely 1α,2β-dihydroxyaristolone (2),9-epidebilon (3),and one rare aristolane-chalcone hybrid,namely 3'-hydroxynardoaristolone A (4) were isolated from the ethanol extract of the roots and rhizomes of Nardostachys chinensis.Their structures were elucidated on the basis of extensive spectroscopic analysis.In addition,the structure of aristolanhydride,recently isolated from the same species,was corrected by reanalysis of the published NMR data.
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| Keywords
Nardostachys chinensis
Aristolane
Secoaristolane
Aristolane-chalcone hybrid
Structural revision
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| Fund:This work was financially supported by the "Large-scale Compound Library" project of National Development and Reform Commission of China. |
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Corresponding Authors:
Fei Wang
E-mail: f.wang@mail.biobiopha.com
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Issue Date: 04 April 2019
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