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Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana |
| Xia Yin1,2, Tao Feng1, Zheng-Hui Li1, Ying Leng3, Ji-Kai Liu1 |
1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China;
2. University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China;
3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China |
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Abstract Five new guanacastane-type diterpenes, named guanacastepenes P-T(1-5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase(11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC50 values of 6.2 and 13.9 μM, respectively.
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| Keywords
Psathyrella candolleana
Psathyrellaceae diterpenes
Guanacastepenes P-T
11β-HSD1
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| Fund:This project was supported by the National Natural Sciences Foundation of China(U1132607, 81373289). |
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Issue Date: 11 February 2018
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