Daphmacrodins A and B, alkaloids from <i>Daphniphyllum macropodum</i>

doi:10.1007/s13659-012-0095-z

Natural Products and Bioprospecting

2013, Vol. 3

Issue (1) : 29-32 DOI: 10.1007/s13659-012-0095-z

Regular Article

Daphmacrodins A and B, alkaloids from Daphniphyllum macropodum

Ming-Ming CAO^a,b, Hong-Ping HE^a, Yu-Cheng GU^c, Qiang ZHANG^d, Xiao-Nian LI^a, Guo-Ying ZUO^e, Ying-Tong DI^a, Chun-Mao YUAN^a, Shun-Lin LI^a, Yu ZHANG^a, Xiao-Jiang HAO^a

a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b University of Chinese Academy of Sciences, Beijing 100049, China;
c Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, RG426 EY, UK;
d Northwest A & F University, Yangling 712100, China;
e Research Center of Natural Medicine, Clinical School of Kunming General Hospital of Chengdu Military Command, Kunming 650032, China

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Abstract Two new daphnicyclidin-type Daphniphyllum alkaloids, daphmacrodins A and B (1 and 2) were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry. The relative configuration of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Their cytotoxic activities against five human cancer cell lines, pesticidal activities against brine shrimp (Artemia salina), and antibacterial activities against five standard bacterial and fungal strains were evaluated. The structure of 1 was successfully transformed to 2 by a chemical method.

Keywords Daphniphyllaceae Daphniphyllum macropodum cyclopentadienyl anion

Issue Date: 11 February 2018

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	Ming-Ming CAO
	Hong-Ping HE
	Yu-Cheng GU
	Qiang ZHANG
	Xiao-Nian LI
	Guo-Ying ZUO
	Ying-Tong DI
	Chun-Mao YUAN
	Shun-Lin LI
	Yu ZHANG
	Xiao-Jiang HAO

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Ming-Ming CAO,Hong-Ping HE,Yu-Cheng GU, et al. Daphmacrodins A and B, alkaloids from Daphniphyllum macropodum[J]. Natural Products and Bioprospecting, 2013, 3(1): 29-32.

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http://npb.kib.ac.cn/EN/10.1007/s13659-012-0095-z OR http://npb.kib.ac.cn/EN/Y2013/V3/I1/29

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