| Short Communication |
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Two new neolignans from Manglietia insignis |
| Shan-Zhai SHANGa,b, Ju-Ming YANa,b, Hai-Bo ZHANGa, Yi-Ming SHIa,b, Zhong-Hua GAOa,b, Xue DUa, Yan LIa, Wei-Lie XIAOa, Han-Dong SUNa |
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China;
b University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Two new neolignans, manneoinsigins A(1) and B(2), together with four known lignans, were isolated from the leaves and stems of Manglietia insignis. The new compounds were established on the basis of extensive spectroscopic analyses. All compounds except 2 were tested for their cytotoxic activity. Compound 3 showed weak cytotoxic activity against the HL-60 human tumor cell line with the IC50 value of 23.5 μM.
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| Keywords
Magnoliaceae
Manglietia insignis
neolignan
cytotoxic activity
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| Fund:This project was supported financially by the NSFC(No. 20802082 and 30830115), the projects from the Chinese Academy of Sciences(KSCX2-EW-Q-10 and KSCX1-YW-R-24), the Major State Basic Research Development Program of China(No. 2009CB522300 and 2009CB940900), and the Natural Science Foundation of Yunnan Province(2012FB178 and 20080A007) and the project of recruited top talent of sciences and technology of Yunnan Province(2009C1120). |
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Issue Date: 11 February 2018
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