Chemical constituents from <i>Munronia sinica</i> and their bioactivities

doi:10.1007/s13659-012-0001-8

Natural Products and Bioprospecting

2012, Vol. 2

Issue (2) : 76-80 DOI: 10.1007/s13659-012-0001-8

Regular Article

Chemical constituents from Munronia sinica and their bioactivities

Xiao-Li LI^a,b, Qiu-Xia HE^c, Feng-Lei ZHANG^d, Yan-Li ZHAO^a,b, Ke-Chun LIU^c, Si-Ping JIANG^,e

a Key Laboratory of Economic Plants and Biotechnology, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
b State Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
c Biology Institute of Shandong Academy of Sciences, Jinan 250014, China;
d Kunming City Institute of Materia Medica, Kunming 650051, China;
e Plateau Institute of Biology, Lhasa 850000, China

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Abstract Two new minor constituents, musinisins A(1) and B(2), together with five known compounds(3-7), were isolated from the aerial parts of Munronia sinica. Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment. Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.

Keywords Munronia sinica chemical constituent musinisin antiangiogenic activity

Fund:This project was supported financially by the Bureau of Science and Technology of Kunming City.

Issue Date: 11 February 2018

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	Qiu-Xia HE
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	Ke-Chun LIU
	Si-Ping JIANG

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Xiao-Li LI,Qiu-Xia HE,Feng-Lei ZHANG, et al. Chemical constituents from Munronia sinica and their bioactivities[J]. Natural Products and Bioprospecting, 2012, 2(2): 76-80.

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http://npb.kib.ac.cn/EN/10.1007/s13659-012-0001-8 OR http://npb.kib.ac.cn/EN/Y2012/V2/I2/76

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